Anti-Viral Immunity and SOCS4

Grant number: 1023559 | Funding period: 2012 - 2014

Completed

Abstract

The SOCS proteins are negative regulators of cytokine signalling and immune cell development and function. SOCS4 is the last remaining SOCS protein for which there is no described function or intracellular target. We intend to use well-defined acute and chronic viral disease models, and investigate the role of SOCS4 in infection in order to unravel its function. We will also search for its binding partners and intracellular targets, and determine the signalling pathways regulated by SOCS4.

Related publications (4)

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Structural influences on the activity of bismuth(III) indole-carboxylato complexes towards Helicobacter pylori and Leishmania

A Pathak, VL Blair, RL Ferrero, L Kedzierski, PC Andrews

2017-12-01

Seven new bismuth(III) complexes derived from indole-carboxylic acids have been synthesised: five are homoleptic; [Bi(IAA)<inf>3</..

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SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity

L Kedzierski, EB Clemens, NL Bird, BT Kile, GT Belz, NA Nicola, K Kedzierska, SE Nicholson

2015-11-01

Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. Mice lacking functional SOCS4..

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Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection

L Kedzierski, EM Linossi, TB Kolesnik, EB Day, NL Bird, BT Kile, GT Belz, D Metcalf, NA Nicola, K Kedzierska, SE Nicholson

2014-01-01

Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biologi..

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Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

EM Linossi, IR Chandrashekaran, TB Kolesnik, JM Murphy, AI Webb, TA Willson, L Kedzierski, AN Bullock, JJ Babon, RS Norton, NA Nicola, SE Nicholson

2013-08-21

Suppressor of Cytokine Signaling (SOCS)5 is thought to act as a tumour suppressor through negative regulation of JAK/STAT and epid..